Comparison of Fecal Microbiota and Polyamine Concentration in Adult Patients with Intractable Atopic Dermatitis and Healthy Adults

Fecal microbiota and polyamine concentration obtained from eleven intractable adult‐type atopic dermatitis (AD) patients and thirteen healthy adults were compared. Fecal microbiota were analyzed using terminal‐restriction fragment length polymorphism. The fecal microbiota of volunteers were divided into two clusters, A (n=16) and B (n=8), and the number of AD patients was found to be higher in Cluster B than Cluster A, suggesting that there are relationships between the obstinacy of intractable adult‐type AD and intestinal microbiota in Cluster B. Fecal spermidine concentration in Cluster B were lower than that in Cluster A significantly (P