Alzheimer disease: presenilin springs a leak
Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the '...
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| Veröffentlicht in: | Nature medicine 2006-10, Vol.12 (10), p.1121-1123 |
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| container_title | Nature medicine |
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| creator | Gandy, Sam Doeven, Mark K Poolman, Bert |
| description | Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease? |
| doi_str_mv | 10.1038/nm1006-1121 |
| format | Article |
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| source | MEDLINE; 2022 ECC(Springer); Springer Nature - Connect here FIRST to enable access |
| subjects | Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - genetics Biomedical and Life Sciences Biomedicine Calcium Calcium - metabolism Cancer Research Endoplasmic Reticulum - metabolism Humans Infectious Diseases Metabolic Diseases Models, Biological Molecular Medicine Mutation Neurosciences news-and-views Peptides Presenilins - genetics Presenilins - metabolism Proteins trans-Golgi Network - metabolism |
| title | Alzheimer disease: presenilin springs a leak |
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