Alzheimer disease: presenilin springs a leak

Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the '...

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Veröffentlicht in:	Nature medicine 2006-10, Vol.12 (10), p.1121-1123
Hauptverfasser:	Gandy, Sam, Doeven, Mark K, Poolman, Bert
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - genetics Biomedical and Life Sciences Biomedicine Calcium Calcium - metabolism Cancer Research Endoplasmic Reticulum - metabolism Humans Infectious Diseases Metabolic Diseases Models, Biological Molecular Medicine Mutation Neurosciences news-and-views Peptides Presenilins - genetics Presenilins - metabolism Proteins trans-Golgi Network - metabolism
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Beschreibung
Zusammenfassung:	Presenilins are thought to contribute to Alzheimer disease through a protein cleavage reaction that produces neurotoxic amyloid-β peptides. A new function for presenilins now comes to light—controlling the leakage of calcium out of the endoplasmic reticulum. Is this a serious challenge to the 'amyloid hypothesis' of Alzheimer disease?
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm1006-1121