Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia

The mutation status of genes encoding the variable region of immunoglobulin heavy chains (IgV(H)) is a strong predictor of disease progression and survival in B-cell chronic lymphocytic leukemia (B-CLL). We investigated whether there is an association between the concentration of both vascular endot...

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Veröffentlicht in:	Haematologica (Roma) 2006-10, Vol.91 (10), p.1432-1433
Hauptverfasser:	Smolej, L, Andrys, C, Pekova, S, Schwarz, J, Belada, D, Zak, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fibroblast Growth Factor 2 - blood Fibroblast Growth Factor 2 - genetics Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Somatic Hypermutation, Immunoglobulin - genetics Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - genetics
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Zusammenfassung:	The mutation status of genes encoding the variable region of immunoglobulin heavy chains (IgV(H)) is a strong predictor of disease progression and survival in B-cell chronic lymphocytic leukemia (B-CLL). We investigated whether there is an association between the concentration of both vascular endothelial growth factor and basic fibroblast growth factor and IgV(H) mutation status in 49 untreated B-CLL patients.
ISSN:	0390-6078 1592-8721