Site-Selective Photocleavage of Proteins by Uranyl Ions

Site-Selective Photocleavage of Proteins by Uranyl Ions

Footprints of a metal: The uranyl ion (UO22+) binds to selected proteins, at specific sites, with high affinities. This property was exploited to photocleave proteins at the UO22+‐binding site. Quenching studies show that free UO22+ is not responsible for the cleavage. This is the first report of pr...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-12, Vol.45 (1), p.137-139
Hauptverfasser: Duff Jr, Michael R., Kumar, Challa V.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cattle
Circular Dichroism
cleavage reactions
Ions - chemistry
Molecular Structure
Molecular Weight
Photochemistry
proteins
Serum Albumin, Bovine - chemistry
Uranium - chemistry
uranyl ions
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Zusammenfassung:Footprints of a metal: The uranyl ion (UO22+) binds to selected proteins, at specific sites, with high affinities. This property was exploited to photocleave proteins at the UO22+‐binding site. Quenching studies show that free UO22+ is not responsible for the cleavage. This is the first report of protein photocleavage with high selectivity by the uranyl ion, upon excitation with visible light.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502344