Highly Efficient Reagents for Br/Mg Exchange

The conversion of electron‐rich aryl bromides into the corresponding Grignard compounds proceeds within 2 h at 25 °C in the presence of 0.55 equivalents of the new reagent sBu2Mg⋅LiCl. The high reactivity of magnesiates is rationalized by quantum chemical model calculations, and selected examples il...

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Veröffentlicht in:	Angewandte Chemie International Edition 2005-12, Vol.45 (1), p.159-162
Hauptverfasser:	Krasovskiy, Arkady, Straub, Bernd F., Knochel, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	bromine-magnesium exchange density functional calculations Grignard reaction lithium Schlenk equilibrium
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Beschreibung
Zusammenfassung:	The conversion of electron‐rich aryl bromides into the corresponding Grignard compounds proceeds within 2 h at 25 °C in the presence of 0.55 equivalents of the new reagent sBu2Mg⋅LiCl. The high reactivity of magnesiates is rationalized by quantum chemical model calculations, and selected examples illustrate the benefits of aryl magnesium compounds for organic syntheses.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200502220