The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations

Summary To better understand the spectrum of adult acute myeloid leukaemia (AML) associated with core binding factor (CBF) translocations, 370 patients with newly diagnosed CBF‐associated AML were analysed. Patients’ age ranged from 16–83 years (median 39 years) with a slight male predominance (55%); 53% had inv(16); 47% had t(8;21). Patients with t(8;21) tended to be younger (P = 0·056), have lower peripheral blood white cell counts (P