Sinonasal Leiomyosarcoma: Review of Literature and Case Report
Objectives/Hypothesis: To determine prognosis of primary sinonasal leiomyosarcomas after treatment. Study Design: Literature review and case report. Methods: Review of English literature from MEDLINE and independent sources with the addition of our case. Results: Including our case, 63 cases have be...
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Veröffentlicht in: | The Laryngoscope 2005-12, Vol.115 (12), p.2242-2248 |
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creator | Ulrich, Christian T. Feiz-Erfan, Iman Spetzler, Robert F. Isaacs, Jeffrey D. Hott, Jonathan S. Nakaji, Peter Coons, Stephen W. Joganic, Edward J. Kresl, John J. Milligan, John M. Lettieri, Salvatore C. |
description | Objectives/Hypothesis: To determine prognosis of primary sinonasal leiomyosarcomas after treatment.
Study Design: Literature review and case report.
Methods: Review of English literature from MEDLINE and independent sources with the addition of our case.
Results: Including our case, 63 cases have been reported. Primary treatment includes resection with or without radiation. Chemotherapy has not been reported to be effective. In our case, however, chemotherapy, consisting of etoposide and high‐dose ifosfamide, caused the tumor to shrink significantly. On the basis of a review of all reported cases, the overall survival rate at a mean follow‐up of 38.24 month is 66%. The minimal overall survival rates at 5 and 10 years are 20% and 6%, respectively.
Conclusion: The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10–year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection. |
doi_str_mv | 10.1097/01.mlg.0000183767.97518.09 |
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Study Design: Literature review and case report.
Methods: Review of English literature from MEDLINE and independent sources with the addition of our case.
Results: Including our case, 63 cases have been reported. Primary treatment includes resection with or without radiation. Chemotherapy has not been reported to be effective. In our case, however, chemotherapy, consisting of etoposide and high‐dose ifosfamide, caused the tumor to shrink significantly. On the basis of a review of all reported cases, the overall survival rate at a mean follow‐up of 38.24 month is 66%. The minimal overall survival rates at 5 and 10 years are 20% and 6%, respectively.
Conclusion: The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10–year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/01.mlg.0000183767.97518.09</identifier><identifier>PMID: 16369174</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adult ; Biological and medical sciences ; Humans ; Leiomyosarcoma - pathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neoplasm Invasiveness ; Nose Neoplasms - pathology ; Otorhinolaryngology. Stomatology ; Paranasal Sinuses - pathology ; Severity of Illness Index</subject><ispartof>The Laryngoscope, 2005-12, Vol.115 (12), p.2242-2248</ispartof><rights>Copyright © 2005 The Triological Society</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5147-9c15093dab72721c3fa6814377ced25076a172b5781f367cf3d75cc7f49338d63</citedby><cites>FETCH-LOGICAL-c5147-9c15093dab72721c3fa6814377ced25076a172b5781f367cf3d75cc7f49338d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.mlg.0000183767.97518.09$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.mlg.0000183767.97518.09$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17379962$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16369174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulrich, Christian T.</creatorcontrib><creatorcontrib>Feiz-Erfan, Iman</creatorcontrib><creatorcontrib>Spetzler, Robert F.</creatorcontrib><creatorcontrib>Isaacs, Jeffrey D.</creatorcontrib><creatorcontrib>Hott, Jonathan S.</creatorcontrib><creatorcontrib>Nakaji, Peter</creatorcontrib><creatorcontrib>Coons, Stephen W.</creatorcontrib><creatorcontrib>Joganic, Edward J.</creatorcontrib><creatorcontrib>Kresl, John J.</creatorcontrib><creatorcontrib>Milligan, John M.</creatorcontrib><creatorcontrib>Lettieri, Salvatore C.</creatorcontrib><title>Sinonasal Leiomyosarcoma: Review of Literature and Case Report</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis: To determine prognosis of primary sinonasal leiomyosarcomas after treatment.
Study Design: Literature review and case report.
Methods: Review of English literature from MEDLINE and independent sources with the addition of our case.
Results: Including our case, 63 cases have been reported. Primary treatment includes resection with or without radiation. Chemotherapy has not been reported to be effective. In our case, however, chemotherapy, consisting of etoposide and high‐dose ifosfamide, caused the tumor to shrink significantly. On the basis of a review of all reported cases, the overall survival rate at a mean follow‐up of 38.24 month is 66%. The minimal overall survival rates at 5 and 10 years are 20% and 6%, respectively.
Conclusion: The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10–year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Leiomyosarcoma - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Nose Neoplasms - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Paranasal Sinuses - pathology</subject><subject>Severity of Illness Index</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMGO0zAQhi0EYruFV0AREtwSPHbsifeAtCp0QYoALSDgZLmOgwxJXOx0l749XlrRM3OZw3zzz-gj5CnQCqjCFxSqcfhe0VzQcJRYKRTQVFTdIwsQHMpaKXGfLChlvGwE-3pGzlP6kXHkgj4kZyC5VID1grz86KcwmWSGonU-jPuQTLRhNBfFtbvx7rYIfdH62UUz76IrzNQVK5Ncnm5DnB-RB70Zknt87Evyef360-pN2b6_eru6bEsroMZSWRBU8c5skCEDy3sjG6g5onUdExSlAWQbgQ30XKLteYfCWuxrxXnTSb4kzw-52xh-7Vya9eiTdcNgJhd2SctGAWXsDrw4gDaGlKLr9Tb60cS9Bqrv7GkKOtvTJ3v6rz2d_1uSJ8cru83outPqUVcGnh0Bk6wZ-mgm69OJQ45KSZa59YG79YPb_8cLur28_iZEDSCAMcxB5SHIp9n9_hdk4k8t8zGhv7y70gI_qPWrttbA_wB2XZqJ</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Ulrich, Christian T.</creator><creator>Feiz-Erfan, Iman</creator><creator>Spetzler, Robert F.</creator><creator>Isaacs, Jeffrey D.</creator><creator>Hott, Jonathan S.</creator><creator>Nakaji, Peter</creator><creator>Coons, Stephen W.</creator><creator>Joganic, Edward J.</creator><creator>Kresl, John J.</creator><creator>Milligan, John M.</creator><creator>Lettieri, Salvatore C.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200512</creationdate><title>Sinonasal Leiomyosarcoma: Review of Literature and Case Report</title><author>Ulrich, Christian T. ; Feiz-Erfan, Iman ; Spetzler, Robert F. ; Isaacs, Jeffrey D. ; Hott, Jonathan S. ; Nakaji, Peter ; Coons, Stephen W. ; Joganic, Edward J. ; Kresl, John J. ; Milligan, John M. ; Lettieri, Salvatore C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5147-9c15093dab72721c3fa6814377ced25076a172b5781f367cf3d75cc7f49338d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Leiomyosarcoma - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Nose Neoplasms - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Paranasal Sinuses - pathology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulrich, Christian T.</creatorcontrib><creatorcontrib>Feiz-Erfan, Iman</creatorcontrib><creatorcontrib>Spetzler, Robert F.</creatorcontrib><creatorcontrib>Isaacs, Jeffrey D.</creatorcontrib><creatorcontrib>Hott, Jonathan S.</creatorcontrib><creatorcontrib>Nakaji, Peter</creatorcontrib><creatorcontrib>Coons, Stephen W.</creatorcontrib><creatorcontrib>Joganic, Edward J.</creatorcontrib><creatorcontrib>Kresl, John J.</creatorcontrib><creatorcontrib>Milligan, John M.</creatorcontrib><creatorcontrib>Lettieri, Salvatore C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulrich, Christian T.</au><au>Feiz-Erfan, Iman</au><au>Spetzler, Robert F.</au><au>Isaacs, Jeffrey D.</au><au>Hott, Jonathan S.</au><au>Nakaji, Peter</au><au>Coons, Stephen W.</au><au>Joganic, Edward J.</au><au>Kresl, John J.</au><au>Milligan, John M.</au><au>Lettieri, Salvatore C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinonasal Leiomyosarcoma: Review of Literature and Case Report</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2005-12</date><risdate>2005</risdate><volume>115</volume><issue>12</issue><spage>2242</spage><epage>2248</epage><pages>2242-2248</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives/Hypothesis: To determine prognosis of primary sinonasal leiomyosarcomas after treatment.
Study Design: Literature review and case report.
Methods: Review of English literature from MEDLINE and independent sources with the addition of our case.
Results: Including our case, 63 cases have been reported. Primary treatment includes resection with or without radiation. Chemotherapy has not been reported to be effective. In our case, however, chemotherapy, consisting of etoposide and high‐dose ifosfamide, caused the tumor to shrink significantly. On the basis of a review of all reported cases, the overall survival rate at a mean follow‐up of 38.24 month is 66%. The minimal overall survival rates at 5 and 10 years are 20% and 6%, respectively.
Conclusion: The prognosis for primary sinonasal leiomyosarcomas is poor. However, a 10–year survival has been reported in a few patients. Chemotherapy may be a useful adjunct when managing extensive lesions unamenable to curative resection.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>16369174</pmid><doi>10.1097/01.mlg.0000183767.97518.09</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Biological and medical sciences Humans Leiomyosarcoma - pathology Magnetic Resonance Imaging Male Medical sciences Neoplasm Invasiveness Nose Neoplasms - pathology Otorhinolaryngology. Stomatology Paranasal Sinuses - pathology Severity of Illness Index |
title | Sinonasal Leiomyosarcoma: Review of Literature and Case Report |
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