Under Pressure: Stromal Fibroblasts Change Their Ways

In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibrobl...

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Veröffentlicht in:	Cell 2005-12, Vol.123 (6), p.985-987
Hauptverfasser:	Bierie, Brian, Moses, Harold L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Connective Tissue - pathology Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Fibroblasts - pathology Male Mice Models, Biological Mutation - genetics Paracrine Communication Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Stromal Cells - pathology Tumor Suppressor Protein p53 - genetics
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Beschreibung
Zusammenfassung:	In this issue of Cell, Hill et al. (2005) demonstrate in a mouse model of prostate cancer that the tumor cells can initiate and promote expansion of stromal fibroblasts that lack the tumor-suppressor protein p53 through a paracrine mechanism. This results in selection of highly proliferative fibroblasts associated with the carcinoma that further promote tumor progression.
ISSN:	0092-8674
DOI:	10.1016/j.cell.2005.11.029