Short report: impact of ivermectin community-level treatments on elimination of adult Onchocerca volvulus when individuals receive multiple treatments per year

A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4x/yr). The effect is particularly ob...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2005-12, Vol.73 (6), p.1159-1161
Hauptverfasser:	Cupp, Eddie W, Cupp, Mary S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cameroon - epidemiology Community Health Services Drug Administration Schedule Female Filaricides - administration & dosage Filaricides - pharmacology Filaricides - therapeutic use Guatemala - epidemiology Humans Ivermectin - administration & dosage Ivermectin - pharmacology Ivermectin - therapeutic use Male Onchocerca volvulus - drug effects Onchocerca volvulus - physiology Onchocerciasis - drug therapy Onchocerciasis - epidemiology Onchocerciasis - etiology Onchocerciasis - parasitology Onchocerciasis - pathology Onchocerciasis - prevention & control Outcome Assessment (Health Care)
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Beschreibung
Zusammenfassung:	A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4x/yr). The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment.
ISSN:	0002-9637
DOI:	10.4269/ajtmh.2005.73.1159