Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2005-11 (44), p.5563-5565
Hauptverfasser:	Vallance, Patrick, Bush, Hannah D, Mok, B James, Hurtado-Guerrero, Ramon, Gill, Herpreet, Rossiter, Sharon, Wilden, Jonathan D, Caddick, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Catalysis Cyclization Hydrolases - antagonists & inhibitors Hydrolases - metabolism Molecular Structure Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Sulfonic Acids - chemical synthesis Sulfonic Acids - chemistry
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Beschreibung
Zusammenfassung:	A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b510709a