Rapid GC–MS analysis of methamphetamine and its metabolites in urine—application of a short narrow-bore capillary column to GC–MS
A rapid analysis of methamphetamine and its metabolites in urine was performed by gas chromatography–mass spectrometry (GC–MS) using a short narrow-bore capillary column (NBC) (5 m × 0.1 mm I.D.). For detection, selected ion monitoring (SIM) was performed for the characteristic ions of each of the c...
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Veröffentlicht in: | Journal of chromatography. B 2006-10, Vol.842 (2), p.116-120 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A rapid analysis of methamphetamine and its metabolites in urine was performed by gas chromatography–mass spectrometry (GC–MS) using a short narrow-bore capillary column (NBC) (5
m
×
0.1
mm I.D.). For detection, selected ion monitoring (SIM) was performed for the characteristic ions of each of the compounds. The analytes were independently detected within 2
min. Linearity was demonstrated over a range from 25–2500
ng/ml. As an application of this study, a urine sample from a drug-abuse suspect was analyzed. The analytes from the actual sample were detected with reasonable reproducibility. The results indicate the possibility of rapid analysis using a conventional GC–MS with a short NBC at a relatively low inlet pressure. |
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ISSN: | 1570-0232 1873-376X |
DOI: | 10.1016/j.jchromb.2006.08.018 |