Lipid-altering efficacy of switching from atorvastatin 10 mg/day to ezetimibe/simvastatin 10/20 mg/day compared to doubling the dose of atorvastatin in hypercholesterolaemic patients with atherosclerosis or coronary heart disease

Lipid-altering efficacy of switching from atorvastatin 10 mg/day to ezetimibe/simvastatin 10/20 mg/day compared to doubling the dose of atorvastatin in hypercholesterolaemic patients with atherosclerosis or coronary heart disease

Summary This randomised, double‐blind study evaluated the efficacy and safety of ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg tablet compared to doubling the atorvastatin (ATV) dose in hypercholesterolaemic patients with atherosclerotic or coronary heart disease (CHD). The study group included 435 mal...

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Veröffentlicht in:International journal of clinical practice (Esher) 2005-12, Vol.59 (12), p.1377-1386
Hauptverfasser: Barrios, V., Amabile, N., Paganelli, F., Chen, J-W, Allen, C., Johnson-Levonas, A. O., Massaad, R., Vandormael, K.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Anticholesteremic Agents - administration & dosage
Apolipoproteins B - blood
Atherosclerosis - complications
Atherosclerosis - drug therapy
Atorvastatin
Atorvastatin Calcium
Azetidines - administration & dosage
Biological and medical sciences
Cardiology. Vascular system
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Disease - complications
Coronary Disease - drug therapy
Coronary heart disease
Double-Blind Method
Drug Therapy, Combination
efficacy
Europe
Ezetimibe
ezetimibe/simvastatin
Female
General aspects
Heart
Heptanoic Acids - administration & dosage
Humans
hypercholesterolaemia
Hypercholesterolemia - complications
Hypercholesterolemia - drug therapy
Male
Medical sciences
Middle Aged
Pyrroles - administration & dosage
Simvastatin - administration & dosage
tablet
Taiwan
Treatment Outcome
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Zusammenfassung:Summary This randomised, double‐blind study evaluated the efficacy and safety of ezetimibe/simvastatin (EZE/SIMVA) 10/20 mg tablet compared to doubling the atorvastatin (ATV) dose in hypercholesterolaemic patients with atherosclerotic or coronary heart disease (CHD). The study group included 435 male and female CHD patients (aged ≥18 years) who had not achieved their low‐density lipoprotein cholesterol (LDL‐C) goal of
ISSN:1368-5031
1742-1241
DOI:10.1111/j.1368-5031.2005.00714.x