Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells

Isoliquiritigenin (ISL), a simple chalcone derivative, 4,2′,4′-trihydroxychalcone, found in licorice, shallot and bean sprouts, has been reported to have chemoprotective effects. To examine the effects of ISL on the growth of prostate cancer cells, we cultured MAT-LyLu (MLL) rat and DU145 human pros...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of nutritional biochemistry 2006-10, Vol.17 (10), p.689-696
Hauptverfasser:	Jung, Jae In, Lim, Soon Sung, Choi, Hyun Ju, Cho, Han Jin, Shin, Hyun-Kyung, Kim, Eun Ji, Chung, Won-Yoon, Park, Kwang-Kyun, Park, Jung Han Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Allium cepa Animals anticarcinogenic activity Apoptosis Apoptosis - drug effects Bcl-2 bean sprouts Biological and medical sciences Blotting, Western Caspase Caspases - analysis Caspases - metabolism cell culture cell cycle Cell Division - drug effects Cell Line, Tumor cell lines cell proliferation chalcone Chalcone - analogs & derivatives Chalcone - pharmacology Chalcones chemical constituents of plants chemoprevention Cytochrome c Cytochromes c - metabolism Enzyme Activation - drug effects Fas Ligand Protein fas Receptor - analysis Feeding. Feeding behavior Flow Cytometry Fundamental and applied biological sciences. Psychology Glycyrrhiza glabra Humans licorice Male Membrane Glycoproteins - analysis Membrane Potentials - drug effects mitochondria Mitochondrial Membranes - drug effects Mitochondrial Membranes - physiology nutritional intervention phenolic compounds Poly(ADP-ribose) Polymerases - analysis Prostate cancer cells prostatic neoplasms Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - analysis Rats shallots Tumor Necrosis Factors - analysis Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Isoliquiritigenin (ISL), a simple chalcone derivative, 4,2′,4′-trihydroxychalcone, found in licorice, shallot and bean sprouts, has been reported to have chemoprotective effects. To examine the effects of ISL on the growth of prostate cancer cells, we cultured MAT-LyLu (MLL) rat and DU145 human prostate cancer cells with various concentrations (0–20 μmol/L) of ISL. Treatment of the cells with increasing concentrations of ISL led to dose-dependent decreases in the viable cell numbers in both DU145 and MLL cells ( P
ISSN:	0955-2863 1873-4847
DOI:	10.1016/j.jnutbio.2005.11.006