Effects of Ge Gen Decoction on PGE2 Content and COX Activity in the Degenarated Cervical Intervertebral Discs of Rats

After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat...

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Veröffentlicht in:	Journal of traditional Chinese medicine 2005-09, Vol.25 (3), p.222-225
1. Verfasser:	周军方素萍霍海如齐云郭淑英姜廷良施杞王友京
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cervical Vertebrae Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Dinoprostone - metabolism Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Female Intervertebral Disc - metabolism Male PGE2 Phytotherapy Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley Spinal Osteophytosis - drug therapy 中医药疗法子宫疾病环氧合酶酶活性
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Zusammenfassung:	After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treatinz cervical spondylosis.
ISSN:	0255-2922