Catechol:  A Minimal Scaffold for Non-Peptide Peptidomimetics of the i + 1 and i + 2 Positions of the β-Turn of Somatostatin

The design, synthesis, and evaluation of a series of catechol-based non-peptide peptidomimetics of the peptide hormone somatostatin have been achieved. These ligands comprise the simplest known non-peptide mimetics of the i + 1 and i + 2 positions of the somatostatin β-turn. Incorporation of an additional side chain to include the i position of the β-turn induces a selective 9-fold affinity enhancement at the sst2 receptor.