Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques...
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| Veröffentlicht in: | Nature medicine 2005-12, Vol.11 (12), p.1293-1294 |
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| container_issue | 12 |
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| container_title | Nature medicine |
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| creator | Veazey, Ronald S Springer, Martin S Marx, Preston A Dufour, Jason Klasse, Per Johan Moore, John P |
| description | Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection. |
| doi_str_mv | 10.1038/nm1321 |
| format | Article |
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We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm1321</identifier><identifier>PMID: 16273102</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Administration, Oral ; Animals ; Biomedical and Life Sciences ; Biomedicine ; brief-communication ; Cancer Research ; CCR5 Receptor Antagonists ; Female ; Human immunodeficiency virus 1 ; Infectious Diseases ; Macaca ; Macaca - virology ; Metabolic Diseases ; Molecular Medicine ; Neurosciences ; Prophylaxis ; Pyrazoles - administration & dosage ; Pyrazoles - pharmacology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian Immunodeficiency Virus - drug effects ; Simian/human immunodeficiency virus ; Time Factors ; Vagina - drug effects ; Vagina - virology ; Valine - administration & dosage ; Valine - analogs & derivatives ; Valine - pharmacology ; Viral Load</subject><ispartof>Nature medicine, 2005-12, Vol.11 (12), p.1293-1294</ispartof><rights>Springer Nature America, Inc. 2005</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-7bac1001960fe21d7fe8bdbcd2ac78c5e6626db49f412a23e8b6667fbafe0f843</citedby><cites>FETCH-LOGICAL-c609t-7bac1001960fe21d7fe8bdbcd2ac78c5e6626db49f412a23e8b6667fbafe0f843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm1321$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm1321$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16273102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veazey, Ronald S</creatorcontrib><creatorcontrib>Springer, Martin S</creatorcontrib><creatorcontrib>Marx, Preston A</creatorcontrib><creatorcontrib>Dufour, Jason</creatorcontrib><creatorcontrib>Klasse, Per Johan</creatorcontrib><creatorcontrib>Moore, John P</creatorcontrib><title>Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). 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Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veazey, Ronald S</au><au>Springer, Martin S</au><au>Marx, Preston A</au><au>Dufour, Jason</au><au>Klasse, Per Johan</au><au>Moore, John P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>11</volume><issue>12</issue><spage>1293</spage><epage>1294</epage><pages>1293-1294</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16273102</pmid><doi>10.1038/nm1321</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2005-12, Vol.11 (12), p.1293-1294 |
| issn | 1078-8956 1546-170X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Administration, Oral Animals Biomedical and Life Sciences Biomedicine brief-communication Cancer Research CCR5 Receptor Antagonists Female Human immunodeficiency virus 1 Infectious Diseases Macaca Macaca - virology Metabolic Diseases Molecular Medicine Neurosciences Prophylaxis Pyrazoles - administration & dosage Pyrazoles - pharmacology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Immunodeficiency Virus - drug effects Simian/human immunodeficiency virus Time Factors Vagina - drug effects Vagina - virology Valine - administration & dosage Valine - analogs & derivatives Valine - pharmacology Viral Load |
| title | Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor |
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