Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques...

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Veröffentlicht in:	Nature medicine 2005-12, Vol.11 (12), p.1293-1294
Hauptverfasser:	Veazey, Ronald S, Springer, Martin S, Marx, Preston A, Dufour, Jason, Klasse, Per Johan, Moore, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biomedical and Life Sciences Biomedicine brief-communication Cancer Research CCR5 Receptor Antagonists Female Human immunodeficiency virus 1 Infectious Diseases Macaca Macaca - virology Metabolic Diseases Molecular Medicine Neurosciences Prophylaxis Pyrazoles - administration & dosage Pyrazoles - pharmacology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Immunodeficiency Virus - drug effects Simian/human immunodeficiency virus Time Factors Vagina - drug effects Vagina - virology Valine - administration & dosage Valine - analogs & derivatives Valine - pharmacology Viral Load
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Beschreibung
Zusammenfassung:	Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm1321