Cathepsin K expression is diminished in infants with bronchopulmonary dysplasia

The expression of a potent collagenolytic enzyme, cathepsin K, was measured in repeated tracheal aspirate samples from premature infants with and without a chronic lung disorder, bronchopulmonary dysplasia (BPD). At 9–13 d, but not before, cathepsin K expression was significantly lower in the lungs...

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Veröffentlicht in:	Acta Paediatrica 2006-10, Vol.95 (10), p.1298-1300
Hauptverfasser:	Knaapi, Jonni, Lukkarinen, Heikki, Kiviranta, Riku, Steiner, Aida, Lassus, Patrick, Andersson, Sture, Kääpä, Pekka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Bronchopulmonary dysplasia Bronchopulmonary Dysplasia - metabolism Cathepsin K Cathepsins - metabolism chronic lung disease Disease Models, Animal Female General aspects Humans Infant, Newborn Male Medical sciences Pneumology Rats Respiratory system : syndromes and miscellaneous diseases
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Beschreibung
Zusammenfassung:	The expression of a potent collagenolytic enzyme, cathepsin K, was measured in repeated tracheal aspirate samples from premature infants with and without a chronic lung disorder, bronchopulmonary dysplasia (BPD). At 9–13 d, but not before, cathepsin K expression was significantly lower in the lungs of premature infants developing BPD. Conclusion: Insufficient pulmonary cathepsin K in BPD may predispose premature lungs to pulmonary fibrosis.
ISSN:	0803-5253 1651-2227
DOI:	10.1080/08035250600586492