Multicomponent Domino Reaction from β-Ketoamides: Highly Efficient Access to Original Polyfunctionalized 2,6-Diazabicyclo[2.2.2]octane Cores

We describe a new multicomponent domino reaction from β-ketoamides, involved as substrates and as nucleophilic partners. We obtain highly functionalized and original 2,6-diazabicyclo[2.2.2]octane cores (2,6-DABCO) in a five-step one-pot sequence, which is fast, environmentally friendly, operationall...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-12, Vol.127 (49), p.17176-17177
Hauptverfasser:	Liéby-Muller, Frédéric, Constantieux, Thierry, Rodriguez, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	We describe a new multicomponent domino reaction from β-ketoamides, involved as substrates and as nucleophilic partners. We obtain highly functionalized and original 2,6-diazabicyclo[2.2.2]octane cores (2,6-DABCO) in a five-step one-pot sequence, which is fast, environmentally friendly, operationally simple to manage, and combines step- and atom-economic aspects.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja055885z