Thermoresponsive Micelles from Oligopeptide-Grafted Cyclotriphosphazenes

Thermoresponsive Micelles from Oligopeptide-Grafted Cyclotriphosphazenes

Hard graft: Amphiphilic cyclic phosphazene trimers grafted with hydrophobic oligopeptide (red) and hydrophilic methoxypolyethylene glycol (blue) show a variety of thermoresponsive properties including lower critical solution temperatures near body temperature. They form strong micelles in aqueous so...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-09, Vol.45 (37), p.6173-6176
Hauptverfasser: Jun, Yong Joo, Toti, Udaya S., Kim, Hye Young, Yu, Ji Young, Jeong, Byeongmoon, Jun, Moo Jin, Sohn, Youn Soo
Format: Artikel
Sprache:eng
Schlagworte:
amphiphiles
drug delivery
Micelles
Nitriles - chemistry
oligopeptides
Oligopeptides - chemistry
Organophosphorus Compounds - chemistry
phosphazenes
Phosphorus Compounds - chemistry
Polymers - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Temperature
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Zusammenfassung:Hard graft: Amphiphilic cyclic phosphazene trimers grafted with hydrophobic oligopeptide (red) and hydrophilic methoxypolyethylene glycol (blue) show a variety of thermoresponsive properties including lower critical solution temperatures near body temperature. They form strong micelles in aqueous solution at an appropriate hydrophobic‐to‐hydrophilic balance.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601108