Peptide conjugates of oligonucleotides: synthesis and applications

This paper examines the synthesis and potential clinical applications of peptide-oligonucleotide conjugates (POCs). It is believed that such compounds may help to surpass the barriers to developing oligonucleotide-based therapeutics.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical reviews 2006-09, Vol.106 (9), p.3712-3761
Hauptverfasser:	Venkatesan, Natarajan, Kim, Byeang Hyean
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical compounds Chemical synthesis Drug therapy Molecular Structure Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Organic chemistry Peptides - chemical synthesis Peptides - chemistry
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Beschreibung
Zusammenfassung:	This paper examines the synthesis and potential clinical applications of peptide-oligonucleotide conjugates (POCs). It is believed that such compounds may help to surpass the barriers to developing oligonucleotide-based therapeutics.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr0502448