Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure

Trimetazidine (TMZ) is effective for the treatment of ischemic cardiomyopathy; however, little is known about the effect of TMZ in established injury‐induced heart failure. When rats with established infarct‐induced heart failure were treated for 12 weeks with TMZ there was no effect on left ventric...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2006-10, Vol.20 (5), p.503-505
Hauptverfasser:	Morgan, Eric E., Young, Martin E., McElfresh, Tracy A., Kung, Theodore A., Hoit, Brian D., Chandler, Margaret P., Stanley, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA Dehydrogenase - genetics Acyl-CoA Dehydrogenase - metabolism Animals Atrial Natriuretic Factor - biosynthesis Atrial Natriuretic Factor - genetics Biological and medical sciences cardiac Cardiology. Vascular system Carnitine O-Palmitoyltransferase - genetics Carnitine O-Palmitoyltransferase - metabolism fatty acid oxidation Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Male Medical sciences metabolism mitochondria Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Palmitoyl-CoA Hydrolase - genetics Palmitoyl-CoA Hydrolase - metabolism Pharmacology. Drug treatments Protein Kinases - genetics Protein Kinases - metabolism Rats Rats, Wistar RNA, Messenger - metabolism Trimetazidine - pharmacology Up-Regulation - drug effects Vasodilator Agents - pharmacology Ventricular Function, Left - drug effects
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Zusammenfassung:	Trimetazidine (TMZ) is effective for the treatment of ischemic cardiomyopathy; however, little is known about the effect of TMZ in established injury‐induced heart failure. When rats with established infarct‐induced heart failure were treated for 12 weeks with TMZ there was no effect on left ventricular function or dilation, or on mRNA expression of fatty acid oxidation enzymes. On the other hand, TMZ significantly reduced atrial natriuretic peptide mRNA levels compared with untreated rats.
ISSN:	0767-3981 1472-8206
DOI:	10.1111/j.1472-8206.2006.00424.x