The Use of Tamoxifen to Improve Height Potential in Short Pubertal Boys

The Use of Tamoxifen to Improve Height Potential in Short Pubertal Boys

A retrospective chart review of 7 pubertal boys who were treated with tamoxifen was conducted to determine the effects of this therapy on skeletal maturation and predicted adult height. Tamoxifen significantly decreased the rate of skeletal maturation and increased the predicted adult height without...

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Veröffentlicht in:Pediatrics (Evanston) 2005-12, Vol.116 (6), p.1513-1515
Hauptverfasser: Kreher, Nerissa C, Eugster, Erica A, Shankar, R. Ravi
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Biological and medical sciences
Body Height
Bone Density Conservation Agents - therapeutic use
Children & youth
Clinical trials
General aspects
Growth Disorders - drug therapy
Height
Humans
Male
Medical sciences
Pediatrics
Physical growth
Puberty
Retrospective Studies
Stature
Tamoxifen
Tamoxifen - therapeutic use
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Beschreibung
Zusammenfassung:A retrospective chart review of 7 pubertal boys who were treated with tamoxifen was conducted to determine the effects of this therapy on skeletal maturation and predicted adult height. Tamoxifen significantly decreased the rate of skeletal maturation and increased the predicted adult height without negative effects on sexual maturation. Additional evaluation of this therapy is now required to determine if the increase in predicted adult height results in a clinically significant increase in final adult height.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2005-0577