Convergent Stereoselective Synthesis of the Visual Pigment A2E

Convergent Stereoselective Synthesis of the Visual Pigment A2E

A stereoselective total synthesis of the visual pigment A2E has been achieved with use of palladium-catalyzed cross-coupling reactions in all key steps:  a regioselective Suzuki or Negishi coupling of 2,4-dibromopyridine, a Sonogashira reaction, and a double Stille cross-coupling to complete the bis...

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Veröffentlicht in:Organic letters 2005-12, Vol.7 (25), p.5737-5739
Hauptverfasser: Sicre, Cristina, Cid, M. Magdalena
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Coloring Agents - chemical synthesis
Coloring Agents - chemistry
Molecular Structure
Palladium - chemistry
Pyridinium Compounds - chemical synthesis
Pyridinium Compounds - chemistry
Retinoids - chemical synthesis
Retinoids - chemistry
Stereoisomerism
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Zusammenfassung:A stereoselective total synthesis of the visual pigment A2E has been achieved with use of palladium-catalyzed cross-coupling reactions in all key steps:  a regioselective Suzuki or Negishi coupling of 2,4-dibromopyridine, a Sonogashira reaction, and a double Stille cross-coupling to complete the bispolyenyl skeleton.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol052512u