Oncolytic potential of rodent parvoviruses for cancer therapy in humans: a brief review

Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, wit...

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Veröffentlicht in:	Journal of veterinary medicine. Series B 2005-09, Vol.52 (7-8), p.327-330
Hauptverfasser:	Geletneky, K, Herrero y Calle, M, Rommelaere, J, Schlehofer, J.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal diseases animal models Animals anticarcinogenic activity Antineoplastic Agents - therapeutic use Cancer carcinogenesis cytotoxicity H-1 parvovirus human diseases Humans literature reviews malignant glioma Medical treatment neoplasms new methods Oncolytic Virotherapy Parvoviridae Infections - veterinary Parvoviridae Infections - virology Parvovirus Rats Rodent Diseases - virology Rodents therapeutics Tumors virology Viruses
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Beschreibung
Zusammenfassung:	Rodent parvoviruses are promising candidates for oncolytic virotherapy of cancer in humans because of their oncotropism (preferential killing of transformed cells) in the absence of pathogenicity. Here, we give an overview concerning the possible application of parvovirus H-1 for cancer therapy, with specific emphasis on malignant brain tumours in humans.
ISSN:	0931-1793 1863-1959 1439-0450 1863-2378
DOI:	10.1111/j.1439-0450.2005.00877.x