Cytotoxic clerodane diterpenoids from Casearia membranacea

Bioassay-guided fractionation of the EtOAc extract of Casearia membranacea leaves and twigs afforded three new clerodane diterpenes, caseamembrins M-O (1-3), and the known rel-(2S,5R,6R,8S,9S,10R,18S,19R)-2-(2-methylbutyryloxy)-6-hydroxy-18,19-di-O-acetyl-18,19-epoxycleroda-3,13(16),14-triene (4) an...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-11, Vol.68 (11), p.1665-1668
Hauptverfasser:	Shen, Y.C, Cheng, Y.B, Ahmed, A.F, Lee, C.L, Chen, S.Y, Chien, C.T, Kuo, Y.H, Tzeng, G.L
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences caseamembrins Casearia Casearia - chemistry Casearia membranacea chemical structure clerodane cultured cells cytotoxicity Diterpenes, Clerodane - chemistry Diterpenes, Clerodane - isolation & purification Diterpenes, Clerodane - pharmacology diterpenoids Drug Screening Assays, Antitumor General pharmacology human health Humans Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant biochemistry plant extracts Plant Leaves - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry Salicaceae spectral analysis stereochemistry Stereoisomerism Taiwan Tumor Cells, Cultured
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Zusammenfassung:	Bioassay-guided fractionation of the EtOAc extract of Casearia membranacea leaves and twigs afforded three new clerodane diterpenes, caseamembrins M-O (1-3), and the known rel-(2S,5R,6R,8S,9S,10R,18S,19R)-2-(2-methylbutyryloxy)-6-hydroxy-18,19-di-O-acetyl-18,19-epoxycleroda-3,13(16),14-triene (4) and caseamembrin D (5). The structures of 1-3, including the relative configurations, were established by extensive NMR spectroscopic analyses. The cytotoxic activities of the isolated diterpenoids against human oral epidermoid (KB), medulla (Med), and colon (DLD-1) cancer cell lines were evaluated.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np058063o