Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum
The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2005-11, Vol.68 (11), p.1588-1591 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Forgo, P Hohmann, J |
| description | The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry. |
| doi_str_mv | 10.1021/np050126f |
| format | Article |
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The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np050126f</identifier><identifier>PMID: 16309304</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>acetylleucovernine ; alkaloids ; Amaryllidaceae Alkaloids - chemistry ; Amaryllidaceae Alkaloids - isolation & purification ; Biological and medical sciences ; chemical structure ; General pharmacology ; Hungary ; Leucojum ; Leucojum vernum ; leucovernine ; Liliaceae ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant biochemistry ; plant extracts ; plant products ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; spectral analysis</subject><ispartof>Journal of natural products (Washington, D.C.), 2005-11, Vol.68 (11), p.1588-1591</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17310425$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16309304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forgo, P</creatorcontrib><creatorcontrib>Hohmann, J</creatorcontrib><title>Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry.</description><subject>acetylleucovernine</subject><subject>alkaloids</subject><subject>Amaryllidaceae Alkaloids - chemistry</subject><subject>Amaryllidaceae Alkaloids - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>chemical structure</subject><subject>General pharmacology</subject><subject>Hungary</subject><subject>Leucojum</subject><subject>Leucojum vernum</subject><subject>leucovernine</subject><subject>Liliaceae</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant biochemistry</subject><subject>plant extracts</subject><subject>plant products</subject><subject>Plant Roots - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>spectral analysis</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0E1PwzAMBuAIgdgYHPgD0AucKDhxk7ZHNBggTYDYxjXKmgR168doVsT-PRkbH6fIrx9bcgg5pnBJgdGragEcKBN2h3QpZxAKYHyXdIEKDDERUYccODcDAISU75OOzyFFiLqkPzRtVn-YpsorE6hKByozy1VR_IsvAlXMVVHn2gW2qcvge2bWlsEatOUh2bOqcOZo-_bIZHA77t-Hw6e7h_71MLQIdBnGU5ZpCmhTkzFIeOJTY1gEaDCh1iBSFfmKa67Rah0pjBOqBcOUcTGdYo-cb_Yumvq9NW4py9xlpihUZerWSZEkmCaceXiyhe20NFoumrxUzUr-nO3B2RYol6nCNqrKcvfnYqQQMe5duHG5W5rP375q5lLEGHM5fh7Jl3Ec3bzCoxx4f7rxVtVSvTV-52TEgPpLIRLr__8CKoJ9Pg</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Forgo, P</creator><creator>Hohmann, J</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum</title><author>Forgo, P ; Hohmann, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f301t-7b2cd103f9ec20858301ee2403e381fe331a44035d5d3fdd4a3781d6239256bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acetylleucovernine</topic><topic>alkaloids</topic><topic>Amaryllidaceae Alkaloids - chemistry</topic><topic>Amaryllidaceae Alkaloids - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>General pharmacology</topic><topic>Hungary</topic><topic>Leucojum</topic><topic>Leucojum vernum</topic><topic>leucovernine</topic><topic>Liliaceae</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant biochemistry</topic><topic>plant extracts</topic><topic>plant products</topic><topic>Plant Roots - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>spectral analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forgo, P</creatorcontrib><creatorcontrib>Hohmann, J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forgo, P</au><au>Hohmann, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>68</volume><issue>11</issue><spage>1588</spage><epage>1591</epage><pages>1588-1591</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>16309304</pmid><doi>10.1021/np050126f</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2005-11, Vol.68 (11), p.1588-1591 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | acetylleucovernine alkaloids Amaryllidaceae Alkaloids - chemistry Amaryllidaceae Alkaloids - isolation & purification Biological and medical sciences chemical structure General pharmacology Hungary Leucojum Leucojum vernum leucovernine Liliaceae Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant biochemistry plant extracts plant products Plant Roots - chemistry Plants, Medicinal - chemistry spectral analysis |
| title | Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum |
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