Leucovernine and acetylleucovernine, alkaloids from Leucojum vernum

The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-11, Vol.68 (11), p.1588-1591
Hauptverfasser:	Forgo, P, Hohmann, J
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylleucovernine alkaloids Amaryllidaceae Alkaloids - chemistry Amaryllidaceae Alkaloids - isolation & purification Biological and medical sciences chemical structure General pharmacology Hungary Leucojum Leucojum vernum leucovernine Liliaceae Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant biochemistry plant extracts plant products Plant Roots - chemistry Plants, Medicinal - chemistry spectral analysis
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Beschreibung
Zusammenfassung:	The fresh bulbs of Leucojum vernum provided seven tyrosine-derived alkaloids; two of them have not been reported before and are named leucovernine and acetylleucovernine. The five known alkaloids were N-demethylgalanthamine, hippeastrine, 9-O-demethylhomolycorine, 5alpha-hydroxyhomolycorine, and 11-hydroxyvittatine. These compounds have been isolated from this species for the first time. The structure determination was carried out by the combination of liquid-phase one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050126f