Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs

Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs

Imidazole modification at C-5 of uridine that is part of tandem G-U wobble base pairs causes slight reduction of thermal stability (DeltaDeltaG(0)(310) < 0.4 kcal mol(-1)) and relatively small change in hydration of short RNA helices.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-12 (46), p.5778-5780
Hauptverfasser: Rozners, Eriks, Smicius, Romualdas, Uchiyama, Chika
Format: Artikel
Sprache:eng
Schlagworte:
Base Pairing
Guanine Nucleotides - chemistry
Imidazoles - chemistry
RNA - chemistry
Transition Temperature
Uracil Nucleotides - chemistry
Water - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Imidazole modification at C-5 of uridine that is part of tandem G-U wobble base pairs causes slight reduction of thermal stability (DeltaDeltaG(0)(310) < 0.4 kcal mol(-1)) and relatively small change in hydration of short RNA helices.
ISSN:1359-7345
1364-548X
DOI:10.1039/b510846b