Massive Insulin Secretion in Response to Anaerobic Exercise in Exercise-induced Hyperinsulinism

Abstract Exercise-induced hyperinsulinism (EIHI) is a recently described entity characterised by recurrent episodes of hypoglycaemia induced by physical exercise. The index patient for this disorder and a matched control were subjected to aerobic and anaerobic exercise tests on a cycle ergometer. Ae...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Hormone and metabolic research 2005-11, Vol.37 (11), p.690-694
Hauptverfasser: Meissner, T., Friedmann, B., Okun, J. G., Schwab, M. A., Otonkoski, T., Bauer, T., Bärtsch, P., Mayatepek, E.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Exercise-induced hyperinsulinism (EIHI) is a recently described entity characterised by recurrent episodes of hypoglycaemia induced by physical exercise. The index patient for this disorder and a matched control were subjected to aerobic and anaerobic exercise tests on a cycle ergometer. Aerobic exercise was performed at an intensity of 60 % of the respective 4 mmol/l lactate threshold (40 min). Anaerobic exercise with an intensity corresponding to 130 % VO 2 max lead to exertion within 2 - 3 min and elicited comparable maximal lactate levels in both subjects (10 - 11 mmol/l). The patient experienced a massive increase in insulin from 34 to 649 mU/l after the anaerobic test, and a lower increase in insulin from 27 to 79 mU/l during the aerobic test. Insulin concentration remained unchanged during both tests in the control. Epinephrine increased in the EIHI patient, which was probably a counterregulatory response to hypoglycaemia. The activity of lactate dehydrogenase of the index patient in isolated leukocytes as well as the response to inhibition of oxamate was normal. The hypothesis of abnormal transport or metabolism of lactate/pyruvate in the β-cells of patients with EIHI was further supported by the parallel increase of lactate and insulin in this study elicited in particular by anaerobic exercise.
ISSN:0018-5043
1439-4286
DOI:10.1055/s-2005-870583