Release of anti-restenosis drugs from poly(ethylene oxide)-poly( dl-lactic-co-glycolic acid) nanoparticles
Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly( dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 °C resulting in 100% release within...
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Veröffentlicht in: | Journal of controlled release 2006-09, Vol.114 (3), p.317-324 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(
dl-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (pH 7.4) at 37 °C resulting in 100% release within 5 h was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved. |
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ISSN: | 0168-3659 1873-4995 |
DOI: | 10.1016/j.jconrel.2006.05.021 |