IgA antibodies, TGF-beta1 and -beta2, and soluble CD14 in the colostrum and development of atopy by age 4

Specific defense factors in breast milk together with length of breast-feeding and genetic predisposition may modulate the development of allergy. We studied whether IgA, soluble CD14 (sCD14), or transforming growth factor (TGF)-beta in colostrum could affect the development of atopy in children up...

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Veröffentlicht in:	Pediatric research 2005-12, Vol.58 (6), p.1300-1305
Hauptverfasser:	Savilahti, Erkki, Siltanen, Mirjami, Kajosaari, Merja, Vaarala, Outi, Saarinen, Kristiina M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - analysis Caseins - immunology Child, Preschool Cohort Studies Colostrum - immunology Female Humans Hypersensitivity, Immediate - etiology Hypersensitivity, Immediate - immunology Immunoglobulin A - analysis Immunoglobulin A - immunology Lipopolysaccharide Receptors - analysis Male Milk - immunology Transforming Growth Factor beta - analysis Transforming Growth Factor beta1 Transforming Growth Factor beta2
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Zusammenfassung:	Specific defense factors in breast milk together with length of breast-feeding and genetic predisposition may modulate the development of allergy. We studied whether IgA, soluble CD14 (sCD14), or transforming growth factor (TGF)-beta in colostrum could affect the development of atopy in children up to age 4. From a cohort of 4676, we selected four groups of children with either long or short exclusive breast-feeding (>3.5 or
ISSN:	0031-3998