Tinker to Evers to Chance: semaphorin signaling takes teamwork

The Rho-family GTPases act downstream of axon guidance receptors, controlling proteins that remodel the cytoskeleton. New work now suggests that these GTPases also team up to regulate activation of the semaphorin-3A receptor itself.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2005-12, Vol.8 (12), p.1635-1636
1. Verfasser:	Garrity, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain - cytology Brain - embryology Brain - metabolism Cell Differentiation - physiology Cellular signal transduction Cytoskeleton - metabolism Genetic aspects Growth Cones - metabolism Growth Cones - ultrastructure Humans Nerve proteins Nerve Tissue Proteins - metabolism Neural Pathways - cytology Neural Pathways - embryology Neural Pathways - metabolism Neural receptors Neurobiology Neurosciences news-and-views Physiological aspects Receptors, Cell Surface - metabolism rho GTP-Binding Proteins - metabolism Semaphorin-3A - metabolism Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	The Rho-family GTPases act downstream of axon guidance receptors, controlling proteins that remodel the cytoskeleton. New work now suggests that these GTPases also team up to regulate activation of the semaphorin-3A receptor itself.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1205-1635