Highly Efficient Rh(I)-Catalyzed Asymmetric Hydrogenation of Enamines Using Monodente Spiro Phosphonite Ligands

A highly enantioselective hydrogenation of nonfunctionalized enamines has been developed by using rhodium complexes of chiral spiro phosphonite ligands, providing chiral tertiary amines in excellent enantioselectivities.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2006-09, Vol.128 (36), p.11774-11775
Hauptverfasser:	Hou, Guo-Hua, Xie, Jian-Hua, Wang, Li-Xin, Zhou, Qi-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Amines - chemical synthesis Amines - chemistry Biphenyl Compounds - chemistry Catalysis Chemistry Exact sciences and technology General and physical chemistry Hydrogen - chemistry Ligands Organophosphonates - chemistry Oxidation-Reduction Pyrrolidines - chemistry Rhodium - chemistry Spiro Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	A highly enantioselective hydrogenation of nonfunctionalized enamines has been developed by using rhodium complexes of chiral spiro phosphonite ligands, providing chiral tertiary amines in excellent enantioselectivities.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0644778