Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates

Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates

PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2005-12 (46), p.5739-5741
Hauptverfasser: Shukla, Rameshwer, Thomas, Thommey P, Peters, Jennifer, Kotlyar, Alina, Myc, Andrzej, Baker, Jr, James R
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - metabolism
Animals
Cell Line
Dendrimers
Drug Delivery Systems - methods
Humans
Integrins - metabolism
Mice
Molecular Structure
Neoplasms - blood supply
Neoplasms - drug therapy
Neovascularization, Pathologic
Oligopeptides - chemistry
Oligopeptides - metabolism
Polyamines - chemistry
Polyamines - metabolism
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Zusammenfassung:PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/b507350b