Munc18 Plays an Important Role in the Regulation of Glutamate Release during Female Puberty Onset

Munc18, a mammalian homolog of C. elegans Unc, is essential for neurotransmitter release. The aim of this study was to identify estrogen-dependent expression of Munc18-1 and its role in the regulation of glutamate release for puberty onset. Hypothalamic munc18-1 mRNA levels were significantly increa...

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Veröffentlicht in:	Molecules and cells 2006-08, Vol.22 (1), p.30-35
Hauptverfasser:	Kim, B.U. (University of Ulsan, Ulsan, Republic of Korea), Choi, J.I. (University of Ulsan, Ulsan, Republic of Korea), Ahn, K.H. (University of Ulsan, Ulsan, Republic of Korea), Jeong, J.K. (University of Ulsan, Ulsan, Republic of Korea), Ha, C.M. (University of Ulsan, Ulsan, Republic of Korea), Jeong, C.S. (University of Ulsan, Ulsan, Republic of Korea), Lee, C.K. (Inje University, Busan, Republic of Korea), Kang, S.G. (Inje University, Gimhae, Republic of Korea), Lee, B.J. (University of Ulsan, Ulsan, Republic of Korea), E-mail: bjlee@ulsan.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE GLUTAMIQUE ACIDO GLUTAMICO Animals Antisense Oligodeoxynucleotide Estradiol Estradiol - pharmacology Female GLUTAMIC ACID Glutamic Acid - metabolism Hypothalamus - metabolism Munc18 Proteins - genetics Munc18 Proteins - physiology Oligodeoxyribonucleotides, Antisense - pharmacology Ovariectomy Ovary - physiology Pubertal Development Rats RNase Protection Assays
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Zusammenfassung:	Munc18, a mammalian homolog of C. elegans Unc, is essential for neurotransmitter release. The aim of this study was to identify estrogen-dependent expression of Munc18-1 and its role in the regulation of glutamate release for puberty onset. Hypothalamic munc18-1 mRNA levels were significantly increased by estrogen treatment in ovariectomized, immature female rats. During pubertal development, the munc18-1 mRNA levels dramatically increased between the juvenile period and the anestrous phase of puberty.
ISSN:	1016-8478
DOI:	10.1016/S1016-8478(23)17387-0