Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas

To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas. Case report. Outpatient practice. Two women with menstrual irregularity, enlarged ovaries, high E2, and normal gonadotropin levels. Cabergoline treatment and transsphenoidal surgery. Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients. Cabergoline was effective in reducing E2 levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas. This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.