Subtype Selective Tetracycline Agonists and their Application for a Two-Stage Regulatory System

We are in control. Rational‐based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA‐1/2 and rtTA‐D have been carried out. These modifications led to a novel two‐stage regulatory system in which two separate genes can be regul...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2006-09, Vol.7 (9), p.1320-1324
Hauptverfasser:	Berens, Christian, Lochner, Susanne, Löber, Stefan, Usai, Igor, Schmidt, Andreas, Drueppel, Lars, Hillen, Wolfgang, Gmeiner, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics chemical biology doxycycline Doxycycline - analogs & derivatives Doxycycline - chemistry Doxycycline - pharmacology gene expression Gene Expression Regulation - drug effects gene technology HeLa Cells Humans Luciferases, Firefly - genetics Luciferases, Firefly - metabolism Luciferases, Renilla - genetics Luciferases, Renilla - metabolism Models, Molecular Molecular Structure Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repressor Proteins - genetics Tetracycline - agonists Tetracycline - chemistry Tetracycline - pharmacology Tetracyclines - chemistry Trans-Activators - genetics Transcriptional Activation - drug effects
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Beschreibung
Zusammenfassung:	We are in control. Rational‐based structural modifications of tetracycline derivatives that can act as selective inducers of the transactivating proteins rtTA‐1/2 and rtTA‐D have been carried out. These modifications led to a novel two‐stage regulatory system in which two separate genes can be regulated by using the selective inducers 9‐dipropylaminodoxycycline (1) and doxycycline (dox).
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200600226