A kinetic model of oxygen regulation of cytochrome production in Escherichia coli

Recent experimental work has identified the principal components arrayed by Escherichia coli in its sensing of, and response to, varying levels of oxygen. This apparatus may be leveraged/modified by the metabolic engineer to identify nonuniform oxygen and glucose regimens that deliver better yields...

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Veröffentlicht in:	Journal of theoretical biology 2006-10, Vol.242 (3), p.547-563
Hauptverfasser:	Peercy, Bradford E., Cox, Steven J., Shalel-Levanon, Sagit, San, Ka-Yiu, Bennett, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobic Anaerobic ArcAB Benzoquinones - metabolism Bioreactors Cytochrome oxidase Cytochromes - biosynthesis Enzyme Activation Escherichia coli Escherichia coli - metabolism Fnr Glucose - metabolism Models, Biological Oxygen - metabolism Oxygen Consumption Transcription control
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Beschreibung
Zusammenfassung:	Recent experimental work has identified the principal components arrayed by Escherichia coli in its sensing of, and response to, varying levels of oxygen. This apparatus may be leveraged/modified by the metabolic engineer to identify nonuniform oxygen and glucose regimens that deliver better yields than their uniform counterparts. Toward this end we build and analyse a mathematical model that captures the role played by oxygen in the regulation of cytochrome production in E. coli.
ISSN:	0022-5193 1095-8541
DOI:	10.1016/j.jtbi.2006.04.006