Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses
Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIV(mac251) challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques t...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2006-09, Vol.353 (1), p.83-98 |
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| creator | Malkevitch, Nina V Patterson, L Jean Aldrich, M Kristine Wu, Yichen Venzon, David Florese, Ruth H Kalyanaraman, V S Pal, Ranajit Lee, Eun Mi Zhao, Jun Cristillo, Anthony Robert-Guroff, Marjorie |
| description | Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIV(mac251) challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques that controlled viremia were re-challenged rectally with SIV(mac251). Strong protection was observed in 8/11 vaccinees, including two exhibiting |
| doi_str_mv | 10.1016/j.virol.2006.05.012 |
| format | Article |
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To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques that controlled viremia were re-challenged rectally with SIV(mac251). Strong protection was observed in 8/11 vaccinees, including two exhibiting <50 SIV RNA copies. Decreased viremia compared to naïve controls was observed in the other three. The SIV-infected unimmunized macaques modestly controlled viremia but exhibited CD4 counts < or =200, unlike the protected macaques. Durable protection was associated with significantly increased SIV-specific ELISPOT responses and lymphoproliferative responses to p27 at re-challenge. After CD8 depletion, 2 of 8 re-challenged, protected vaccinees maintained <50 SIV RNA copies; SIV RNA emerged in 6. Re-appearance of CD8 cells and restoration of SIV-specific cellular immunity coincided with viremia suppression. 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Patterson, L Jean ; Aldrich, M Kristine ; Wu, Yichen ; Venzon, David ; Florese, Ruth H ; Kalyanaraman, V S ; Pal, Ranajit ; Lee, Eun Mi ; Zhao, Jun ; Cristillo, Anthony ; Robert-Guroff, Marjorie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-2b6874730d881da52c7aef40ced01057135adf019b6cd96d7fdef7b42b3141463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenoviridae - genetics</topic><topic>Adenoviridae - immunology</topic><topic>Administration, Rectal</topic><topic>Animals</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Immunity, Cellular</topic><topic>Immunization, Secondary</topic><topic>Macaca mulatta</topic><topic>Recombinant Fusion Proteins - immunology</topic><topic>RNA, Viral - analysis</topic><topic>SAIDS Vaccines - administration & dosage</topic><topic>SAIDS Vaccines - genetics</topic><topic>SAIDS Vaccines - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Simian Acquired Immunodeficiency Syndrome - virology</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>Simian Immunodeficiency Virus - isolation & purification</topic><topic>Time Factors</topic><topic>Vaccination</topic><topic>Vaccines, Synthetic - administration & dosage</topic><topic>Viremia</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malkevitch, Nina V</creatorcontrib><creatorcontrib>Patterson, L Jean</creatorcontrib><creatorcontrib>Aldrich, M Kristine</creatorcontrib><creatorcontrib>Wu, Yichen</creatorcontrib><creatorcontrib>Venzon, David</creatorcontrib><creatorcontrib>Florese, Ruth H</creatorcontrib><creatorcontrib>Kalyanaraman, V S</creatorcontrib><creatorcontrib>Pal, Ranajit</creatorcontrib><creatorcontrib>Lee, Eun Mi</creatorcontrib><creatorcontrib>Zhao, Jun</creatorcontrib><creatorcontrib>Cristillo, Anthony</creatorcontrib><creatorcontrib>Robert-Guroff, Marjorie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malkevitch, Nina V</au><au>Patterson, L Jean</au><au>Aldrich, M Kristine</au><au>Wu, Yichen</au><au>Venzon, David</au><au>Florese, Ruth H</au><au>Kalyanaraman, V S</au><au>Pal, Ranajit</au><au>Lee, Eun Mi</au><au>Zhao, Jun</au><au>Cristillo, Anthony</au><au>Robert-Guroff, Marjorie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2006-09-15</date><risdate>2006</risdate><volume>353</volume><issue>1</issue><spage>83</spage><epage>98</epage><pages>83-98</pages><issn>0042-6822</issn><abstract>Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIV(mac251) challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques that controlled viremia were re-challenged rectally with SIV(mac251). Strong protection was observed in 8/11 vaccinees, including two exhibiting <50 SIV RNA copies. Decreased viremia compared to naïve controls was observed in the other three. The SIV-infected unimmunized macaques modestly controlled viremia but exhibited CD4 counts < or =200, unlike the protected macaques. Durable protection was associated with significantly increased SIV-specific ELISPOT responses and lymphoproliferative responses to p27 at re-challenge. After CD8 depletion, 2 of 8 re-challenged, protected vaccinees maintained <50 SIV RNA copies; SIV RNA emerged in 6. Re-appearance of CD8 cells and restoration of SIV-specific cellular immunity coincided with viremia suppression. Overall, cellular immunity induced by vaccination and/or low-level, inapparent viremia post-first SIV(mac251) challenge, was associated with durable protection against re-challenge.</abstract><cop>United States</cop><pmid>16814356</pmid><doi>10.1016/j.virol.2006.05.012</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Virology (New York, N.Y.), 2006-09, Vol.353 (1), p.83-98 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoviridae - genetics Adenoviridae - immunology Administration, Rectal Animals CD8-Positive T-Lymphocytes - immunology Immunity, Cellular Immunization, Secondary Macaca mulatta Recombinant Fusion Proteins - immunology RNA, Viral - analysis SAIDS Vaccines - administration & dosage SAIDS Vaccines - genetics SAIDS Vaccines - immunology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - isolation & purification Time Factors Vaccination Vaccines, Synthetic - administration & dosage Viremia Virus Replication |
| title | Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses |
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