Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses

Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses

Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIV(mac251) challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques t...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 2006-09, Vol.353 (1), p.83-98
Hauptverfasser: Malkevitch, Nina V, Patterson, L Jean, Aldrich, M Kristine, Wu, Yichen, Venzon, David, Florese, Ruth H, Kalyanaraman, V S, Pal, Ranajit, Lee, Eun Mi, Zhao, Jun, Cristillo, Anthony, Robert-Guroff, Marjorie
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviridae - genetics
Adenoviridae - immunology
Administration, Rectal
Animals
CD8-Positive T-Lymphocytes - immunology
Immunity, Cellular
Immunization, Secondary
Macaca mulatta
Recombinant Fusion Proteins - immunology
RNA, Viral - analysis
SAIDS Vaccines - administration & dosage
SAIDS Vaccines - genetics
SAIDS Vaccines - immunology
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - prevention & control
Simian Acquired Immunodeficiency Syndrome - virology
Simian Immunodeficiency Virus - immunology
Simian Immunodeficiency Virus - isolation & purification
Time Factors
Vaccination
Vaccines, Synthetic - administration & dosage
Viremia
Virus Replication
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Zusammenfassung:Previously, priming with replication-competent adenovirus-SIV multigenic vaccines and boosting with envelope subunits strongly protected 39% of rhesus macaques against rectal SIV(mac251) challenge. To evaluate protection durability, eleven of the protected and two SIV-infected unimmunized macaques that controlled viremia were re-challenged rectally with SIV(mac251). Strong protection was observed in 8/11 vaccinees, including two exhibiting
ISSN:0042-6822
DOI:10.1016/j.virol.2006.05.012