Synthesis and antiproliferative activity of 2,6-Dibenzylamino-3,5-dicyanopyridines on human cancer cell lines

A new series of 2,6-dibenzylamino-3,5-dicyanopyridines were synthesized and evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancer. Some of newly prepared compounds demonstrated remarkable anticancer activity against most of the tested subpanel tum...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2005-12, Vol.40 (12), p.1365-1372
Hauptverfasser:	Cocco, Maria Teresa, Congiu, Cenzo, Lilliu, Valentina, Onnis, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cytostatic activity Dicyanopyridines Drug Screening Assays, Antitumor General aspects Humans Medical sciences Molecular Structure Pharmacology. Drug treatments Pyridines Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new series of 2,6-dibenzylamino-3,5-dicyanopyridines were synthesized and evaluated for their in vitro anticancer activity toward cell lines of nine different types of human cancer. Some of newly prepared compounds demonstrated remarkable anticancer activity against most of the tested subpanel tumor cell lines.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/j.ejmech.2005.07.005