An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization

The iodocyclization of acetoxy-containing 2-(1-alkynyl)anisoles and subsequent direct palladium-catalyzed carbonylation/lactonization provide an efficient route to naturally occurring coumestan and coumestrol, and their related analogues.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2005-11, Vol.70 (24), p.9985-9989
Hauptverfasser:	Yao, Tuanli, Yue, Dawei, Larock, Richard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Chemistry Coumarins - chemical synthesis Coumarins - chemistry Coumestrol - chemical synthesis Coumestrol - chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Iodine - chemistry Molecular Structure Organic chemistry Palladium - chemistry Preparations and properties
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