An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization

The iodocyclization of acetoxy-containing 2-(1-alkynyl)anisoles and subsequent direct palladium-catalyzed carbonylation/lactonization provide an efficient route to naturally occurring coumestan and coumestrol, and their related analogues.

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Veröffentlicht in:Journal of organic chemistry 2005-11, Vol.70 (24), p.9985-9989
Hauptverfasser: Yao, Tuanli, Yue, Dawei, Larock, Richard C
Format: Artikel
Sprache:eng
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Zusammenfassung:The iodocyclization of acetoxy-containing 2-(1-alkynyl)anisoles and subsequent direct palladium-catalyzed carbonylation/lactonization provide an efficient route to naturally occurring coumestan and coumestrol, and their related analogues.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0517038