Alterations of T-lymphocyte populations in Parkinson disease

Alterations of T-lymphocyte populations in Parkinson disease

Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly...

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Veröffentlicht in:Parkinsonism & related disorders 2005-12, Vol.11 (8), p.493-498
Hauptverfasser: Baba, Yasuhiko, Kuroiwa, Ataru, Uitti, Ryan J., Wszolek, Zbigniew K., Yamada, Tatsuo
Format: Artikel
Sprache:eng
Schlagworte:
Aged
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cytokine
Cytokines - blood
Female
Flow Cytometry
Humans
Immunologic alteration
Interferon-gamma - blood
Interleukin-4 - blood
Lymphocyte Count
Male
Middle Aged
Parkinson disease
Parkinson Disease - immunology
Receptors, Interleukin-2
Sex Characteristics
T lymphocyte
T-Lymphocytes - physiology
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Zusammenfassung:Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4 +:CD8 +T-cell ratios ( P
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2005.07.005