Regiospecific and Stereoselective Syntheses of (±)-Reserpine and (−)-Reserpine

Full details of three approaches to an entirely regio- and stereoselective synthesis of the well-known target reserpine are described, culminating in a total synthesis which efficiently meets these requirements.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2005-11, Vol.127 (46), p.16255-16262
Hauptverfasser:	Stork, Gilbert, Tang, Peng Cho, Casey, Michael, Goodman, Burton, Toyota, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Medical sciences Molecular Structure Neuropharmacology Organic chemistry Pharmacology. Drug treatments Preparations and properties Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Reserpine - chemical synthesis Reserpine - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	Full details of three approaches to an entirely regio- and stereoselective synthesis of the well-known target reserpine are described, culminating in a total synthesis which efficiently meets these requirements.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja055744x