RNAi: RISC Gets Loaded

When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two ∼21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA stran...

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Veröffentlicht in:	Cell 2005-11, Vol.123 (4), p.543-545
Hauptverfasser:	Preall, Jonathan B., Sontheimer, Erik J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Humans MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic RNA Interference - physiology RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-Induced Silencing Complex - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	When an siRNA or miRNA proceeds through the RNA-induced silencing complex assembly pathway, only one of the two ∼21-nucleotide RNA strands survives in the final, active complex. In this issue of Cell, Matranga et al. (2005) and Rand et al. (2005) reveal the fate of the rejected passenger siRNA strand. Additionally, Gregory et al. (2005) define a heterotrimeric complex from humans that appears to execute dsRNA loading, strand selection, and target mRNA cleavage activities.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2005.11.006