Prins Cyclizations in Au-Catalyzed Reactions of Enynes

Going for gold: AuI‐catalyzed cyclizations of functionalized enynes lead to the ready assembly of tricyclic carbon skeletons that are present in a number of naturally occurring compounds. An alkenyl gold intermediate is formed in the cyclization of the enynes and can be trapped in 5‐exo‐dig or 6‐end...

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Veröffentlicht in:	Angewandte Chemie International Edition 2006-08, Vol.45 (33), p.5452-5455
Hauptverfasser:	Jiménez-Núñez, Eloísa, Claverie, Christelle K., Nieto-Oberhuber, Cristina, Echavarren, Antonio M.
Format:	Artikel
Sprache:	eng
Schlagworte:	cyclization enynes gold Prins reaction rearrangements
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Going for gold: AuI‐catalyzed cyclizations of functionalized enynes lead to the ready assembly of tricyclic carbon skeletons that are present in a number of naturally occurring compounds. An alkenyl gold intermediate is formed in the cyclization of the enynes and can be trapped in 5‐exo‐dig or 6‐endo‐dig Prins reactions to form an additional CC bond. Z=C(CO2Me)2, NTs; R=H, Me, iPr.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200601575