Lipoyl Synthase Inserts Sulfur Atoms into an Octanoyl Substrate in a Stepwise Manner

Lipoyl Synthase Inserts Sulfur Atoms into an Octanoyl Substrate in a Stepwise Manner

One step at a time: The insertion of the two sulfur atoms found in lipoyl groups requires the enzyme lipoyl synthase (LipA). The order of insertion of the two sulfur groups has been elucidated by spectroscopic characterization of a monothiolated species.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-08, Vol.45 (31), p.5197-5199
Hauptverfasser: Douglas, Paul, Kriek, Marco, Bryant, Penny, Roach, Peter L.
Format: Artikel
Sprache:eng
Schlagworte:
Bacterial Proteins - metabolism
biosynthesis
cofactors
enzyme models
insertion
lipoic acid
Molecular Structure
Substrate Specificity
Sulfolobus solfataricus - enzymology
Sulfur - chemistry
Sulfur - metabolism
Thioctic Acid - chemical synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:One step at a time: The insertion of the two sulfur atoms found in lipoyl groups requires the enzyme lipoyl synthase (LipA). The order of insertion of the two sulfur groups has been elucidated by spectroscopic characterization of a monothiolated species.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601910